Sibling versus Unrelated Donor Allogeneic Hematopoietic Cell Transplantation for CML: Refined HLA-matching shows more GVHD but not less relapse
Identifieur interne : 007B62 ( Main/Exploration ); précédent : 007B61; suivant : 007B63Sibling versus Unrelated Donor Allogeneic Hematopoietic Cell Transplantation for CML: Refined HLA-matching shows more GVHD but not less relapse
Auteurs : Daniel J. Weisdorf [États-Unis] ; Gene Nelson [États-Unis] ; Stephanie J. Lee [États-Unis] ; Michael Haagenson [États-Unis] ; Stephen Spellman [États-Unis] ; Joseph H. Antin [États-Unis] ; Brian Bolwell [États-Unis] ; Jean-Yves Cahn [France] ; Francisco Cervantes [Espagne] ; Edward Copelan [États-Unis] ; Robert Gale [États-Unis] ; Alois Gratwohl [Suisse] ; H. Jean Khoury [Géorgie (pays)] ; Philip Mccarthy [États-Unis] ; David I. Marks [Royaume-Uni] ; Jeff Szer [Australie] ; Ann Woolfrey [États-Unis] ; Jorge Cortes-Franco [États-Unis] ; Mary M. Horowitz [États-Unis] ; Mukta Arora [États-Unis]Source :
- Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation [ 1083-8791 ] ; 2009.
Abstract
Unrelated donor (URD) hematopoietic cell transplantation (HCT) can eradicate chronic myelogenous leukemia (CML). It has been postulated that greater donor:recipient-histoincompatibility can augment the graft vs. leukemia (GvL) effect. We previously reported similar, but not equivalent outcomes of URD vs. sibling donor HCT for CML using an older, less precise classification of HLA-matching.
Our recently refined HLA-matching classification, suitable for interpretation when complete allele-level typing is unavailable was used to reanalyze outcomes of previous HCT for CML.
We observed that new matching criteria identifies substantially more frequent mismatch than older, less precise “6 of 6 antigen” matched URD-HCT. Only 37% of those previously called “HLA-matched” were HLA-
These data confirm the utility of our revised HLA-matching schema as applicable for analysis of retrospective data sets when fully informative, allele level-typing is unavailable. In this analysis, greater histoincompatibility can augment GVHD but does not improve protection against relapse thus the best donor is still the most closely matched.
Url:
DOI: 10.1016/j.bbmt.2009.06.016
PubMed: 19822308
PubMed Central: 2929002
Affiliations:
- Australie, Espagne, France, Géorgie (pays), Royaume-Uni, Suisse, États-Unis
- Bourgogne-Franche-Comté, Californie, Franche-Comté, Massachusetts, Minnesota, Ohio, Texas, Washington (État), Wisconsin, État de New York
- Besançon
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 001492
- to stream Pmc, to step Curation: 001352
- to stream Pmc, to step Checkpoint: 002729
- to stream Ncbi, to step Merge: 000658
- to stream Ncbi, to step Curation: 000658
- to stream Ncbi, to step Checkpoint: 000658
- to stream Main, to step Merge: 008217
- to stream Main, to step Curation: 007B62
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Sibling versus Unrelated Donor Allogeneic Hematopoietic Cell Transplantation for CML: Refined HLA-matching shows more GVHD but not less relapse</title>
<author><name sortKey="Weisdorf, Daniel J" sort="Weisdorf, Daniel J" uniqKey="Weisdorf D" first="Daniel J." last="Weisdorf">Daniel J. Weisdorf</name>
<affiliation wicri:level="2"><nlm:aff id="A1">University of Minnesota, Minneapolis, Minnesota</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>University of Minnesota, Minneapolis</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A2">Center for International Blood and Marrow Transplant Research, Minneapolis, Minnesota</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Center for International Blood and Marrow Transplant Research, Minneapolis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Nelson, Gene" sort="Nelson, Gene" uniqKey="Nelson G" first="Gene" last="Nelson">Gene Nelson</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Center for International Blood and Marrow Transplant Research, Minneapolis, Minnesota</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Center for International Blood and Marrow Transplant Research, Minneapolis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Lee, Stephanie J" sort="Lee, Stephanie J" uniqKey="Lee S" first="Stephanie J" last="Lee">Stephanie J. Lee</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Center for International Blood and Marrow Transplant Research, Minneapolis, Minnesota</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Center for International Blood and Marrow Transplant Research, Minneapolis</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A3">Fred Hutchinson Cancer Research Center, Seattle, Washington</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Haagenson, Michael" sort="Haagenson, Michael" uniqKey="Haagenson M" first="Michael" last="Haagenson">Michael Haagenson</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Center for International Blood and Marrow Transplant Research, Minneapolis, Minnesota</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Center for International Blood and Marrow Transplant Research, Minneapolis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Spellman, Stephen" sort="Spellman, Stephen" uniqKey="Spellman S" first="Stephen" last="Spellman">Stephen Spellman</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Center for International Blood and Marrow Transplant Research, Minneapolis, Minnesota</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Center for International Blood and Marrow Transplant Research, Minneapolis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Antin, Joseph H" sort="Antin, Joseph H" uniqKey="Antin J" first="Joseph H" last="Antin">Joseph H. Antin</name>
<affiliation wicri:level="2"><nlm:aff id="A4">Dana Farber Cancer Institute, Boston, Massachusetts</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Dana Farber Cancer Institute, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Bolwell, Brian" sort="Bolwell, Brian" uniqKey="Bolwell B" first="Brian" last="Bolwell">Brian Bolwell</name>
<affiliation wicri:level="2"><nlm:aff id="A5">Cleveland Clinic, Cleveland, Ohio</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Cleveland Clinic, Cleveland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Cahn, Jean Yves" sort="Cahn, Jean Yves" uniqKey="Cahn J" first="Jean-Yves" last="Cahn">Jean-Yves Cahn</name>
<affiliation wicri:level="3"><nlm:aff id="A6">Besançon University Hospital, Besançon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Besançon University Hospital, Besançon</wicri:regionArea>
<placeName><region type="region">Bourgogne-Franche-Comté</region>
<region type="old region">Franche-Comté</region>
<settlement type="city">Besançon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cervantes, Francisco" sort="Cervantes, Francisco" uniqKey="Cervantes F" first="Francisco" last="Cervantes">Francisco Cervantes</name>
<affiliation wicri:level="1"><nlm:aff id="A7">Hospital Clínic, IDIBAPS, University of Barcelona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Hospital Clínic, IDIBAPS, University of Barcelona</wicri:regionArea>
<wicri:noRegion>University of Barcelona</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Copelan, Edward" sort="Copelan, Edward" uniqKey="Copelan E" first="Edward" last="Copelan">Edward Copelan</name>
<affiliation wicri:level="2"><nlm:aff id="A5">Cleveland Clinic, Cleveland, Ohio</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Cleveland Clinic, Cleveland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Gale, Robert" sort="Gale, Robert" uniqKey="Gale R" first="Robert" last="Gale">Robert Gale</name>
<affiliation wicri:level="2"><nlm:aff id="A8">Center for Advanced Studies in Leukemia, Los Angeles, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Center for Advanced Studies in Leukemia, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Gratwohl, Alois" sort="Gratwohl, Alois" uniqKey="Gratwohl A" first="Alois" last="Gratwohl">Alois Gratwohl</name>
<affiliation wicri:level="1"><nlm:aff id="A9">University of Basel, Basel, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>University of Basel, Basel</wicri:regionArea>
<wicri:noRegion>Basel</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Khoury, H Jean" sort="Khoury, H Jean" uniqKey="Khoury H" first="H. Jean" last="Khoury">H. Jean Khoury</name>
<affiliation wicri:level="1"><nlm:aff id="A10">Emory Clinic, Winship Cancer Institute, Atlanta, Georgia</nlm:aff>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Emory Clinic, Winship Cancer Institute, Atlanta</wicri:regionArea>
<wicri:noRegion>Atlanta</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mccarthy, Philip" sort="Mccarthy, Philip" uniqKey="Mccarthy P" first="Philip" last="Mccarthy">Philip Mccarthy</name>
<affiliation wicri:level="2"><nlm:aff id="A11">Roswell Park Cancer Institute, Buffalo, New York</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Roswell Park Cancer Institute, Buffalo</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Marks, David I" sort="Marks, David I" uniqKey="Marks D" first="David I" last="Marks">David I. Marks</name>
<affiliation wicri:level="1"><nlm:aff id="A12">United Bristol Healthcare Trust, Bristol, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>United Bristol Healthcare Trust, Bristol</wicri:regionArea>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Szer, Jeff" sort="Szer, Jeff" uniqKey="Szer J" first="Jeff" last="Szer">Jeff Szer</name>
<affiliation wicri:level="1"><nlm:aff id="A13">Royal Melbourne and Western Hospitals, Parkville, Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Royal Melbourne and Western Hospitals, Parkville, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Woolfrey, Ann" sort="Woolfrey, Ann" uniqKey="Woolfrey A" first="Ann" last="Woolfrey">Ann Woolfrey</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Fred Hutchinson Cancer Research Center, Seattle, Washington</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Cortes Franco, Jorge" sort="Cortes Franco, Jorge" uniqKey="Cortes Franco J" first="Jorge" last="Cortes-Franco">Jorge Cortes-Franco</name>
<affiliation wicri:level="2"><nlm:aff id="A14">University of Texas, M.D. Anderson Cancer Center, Houston, Texas</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>University of Texas, M.D. Anderson Cancer Center, Houston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Horowitz, Mary M" sort="Horowitz, Mary M" uniqKey="Horowitz M" first="Mary M" last="Horowitz">Mary M. Horowitz</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Center for International Blood and Marrow Transplant Research, Minneapolis, Minnesota</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Center for International Blood and Marrow Transplant Research, Minneapolis</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A15">Medical College of Wisconsin, Milwaukee, Wisconsin</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>Medical College of Wisconsin, Milwaukee</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Arora, Mukta" sort="Arora, Mukta" uniqKey="Arora M" first="Mukta" last="Arora">Mukta Arora</name>
<affiliation wicri:level="2"><nlm:aff id="A1">University of Minnesota, Minneapolis, Minnesota</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>University of Minnesota, Minneapolis</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A2">Center for International Blood and Marrow Transplant Research, Minneapolis, Minnesota</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Center for International Blood and Marrow Transplant Research, Minneapolis</wicri:cityArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">19822308</idno>
<idno type="pmc">2929002</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2929002</idno>
<idno type="RBID">PMC:2929002</idno>
<idno type="doi">10.1016/j.bbmt.2009.06.016</idno>
<date when="2009">2009</date>
<idno type="wicri:Area/Pmc/Corpus">001492</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001492</idno>
<idno type="wicri:Area/Pmc/Curation">001352</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001352</idno>
<idno type="wicri:Area/Pmc/Checkpoint">002729</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002729</idno>
<idno type="wicri:Area/Ncbi/Merge">000658</idno>
<idno type="wicri:Area/Ncbi/Curation">000658</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000658</idno>
<idno type="wicri:doubleKey">1083-8791:2009:Weisdorf D:sibling:versus:unrelated</idno>
<idno type="wicri:Area/Main/Merge">008217</idno>
<idno type="wicri:Area/Main/Curation">007B62</idno>
<idno type="wicri:Area/Main/Exploration">007B62</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Sibling versus Unrelated Donor Allogeneic Hematopoietic Cell Transplantation for CML: Refined HLA-matching shows more GVHD but not less relapse</title>
<author><name sortKey="Weisdorf, Daniel J" sort="Weisdorf, Daniel J" uniqKey="Weisdorf D" first="Daniel J." last="Weisdorf">Daniel J. Weisdorf</name>
<affiliation wicri:level="2"><nlm:aff id="A1">University of Minnesota, Minneapolis, Minnesota</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>University of Minnesota, Minneapolis</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A2">Center for International Blood and Marrow Transplant Research, Minneapolis, Minnesota</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Center for International Blood and Marrow Transplant Research, Minneapolis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Nelson, Gene" sort="Nelson, Gene" uniqKey="Nelson G" first="Gene" last="Nelson">Gene Nelson</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Center for International Blood and Marrow Transplant Research, Minneapolis, Minnesota</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Center for International Blood and Marrow Transplant Research, Minneapolis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Lee, Stephanie J" sort="Lee, Stephanie J" uniqKey="Lee S" first="Stephanie J" last="Lee">Stephanie J. Lee</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Center for International Blood and Marrow Transplant Research, Minneapolis, Minnesota</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Center for International Blood and Marrow Transplant Research, Minneapolis</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A3">Fred Hutchinson Cancer Research Center, Seattle, Washington</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Haagenson, Michael" sort="Haagenson, Michael" uniqKey="Haagenson M" first="Michael" last="Haagenson">Michael Haagenson</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Center for International Blood and Marrow Transplant Research, Minneapolis, Minnesota</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Center for International Blood and Marrow Transplant Research, Minneapolis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Spellman, Stephen" sort="Spellman, Stephen" uniqKey="Spellman S" first="Stephen" last="Spellman">Stephen Spellman</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Center for International Blood and Marrow Transplant Research, Minneapolis, Minnesota</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Center for International Blood and Marrow Transplant Research, Minneapolis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Antin, Joseph H" sort="Antin, Joseph H" uniqKey="Antin J" first="Joseph H" last="Antin">Joseph H. Antin</name>
<affiliation wicri:level="2"><nlm:aff id="A4">Dana Farber Cancer Institute, Boston, Massachusetts</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Dana Farber Cancer Institute, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Bolwell, Brian" sort="Bolwell, Brian" uniqKey="Bolwell B" first="Brian" last="Bolwell">Brian Bolwell</name>
<affiliation wicri:level="2"><nlm:aff id="A5">Cleveland Clinic, Cleveland, Ohio</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Cleveland Clinic, Cleveland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Cahn, Jean Yves" sort="Cahn, Jean Yves" uniqKey="Cahn J" first="Jean-Yves" last="Cahn">Jean-Yves Cahn</name>
<affiliation wicri:level="3"><nlm:aff id="A6">Besançon University Hospital, Besançon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Besançon University Hospital, Besançon</wicri:regionArea>
<placeName><region type="region">Bourgogne-Franche-Comté</region>
<region type="old region">Franche-Comté</region>
<settlement type="city">Besançon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cervantes, Francisco" sort="Cervantes, Francisco" uniqKey="Cervantes F" first="Francisco" last="Cervantes">Francisco Cervantes</name>
<affiliation wicri:level="1"><nlm:aff id="A7">Hospital Clínic, IDIBAPS, University of Barcelona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Hospital Clínic, IDIBAPS, University of Barcelona</wicri:regionArea>
<wicri:noRegion>University of Barcelona</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Copelan, Edward" sort="Copelan, Edward" uniqKey="Copelan E" first="Edward" last="Copelan">Edward Copelan</name>
<affiliation wicri:level="2"><nlm:aff id="A5">Cleveland Clinic, Cleveland, Ohio</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Cleveland Clinic, Cleveland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Gale, Robert" sort="Gale, Robert" uniqKey="Gale R" first="Robert" last="Gale">Robert Gale</name>
<affiliation wicri:level="2"><nlm:aff id="A8">Center for Advanced Studies in Leukemia, Los Angeles, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Center for Advanced Studies in Leukemia, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Gratwohl, Alois" sort="Gratwohl, Alois" uniqKey="Gratwohl A" first="Alois" last="Gratwohl">Alois Gratwohl</name>
<affiliation wicri:level="1"><nlm:aff id="A9">University of Basel, Basel, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>University of Basel, Basel</wicri:regionArea>
<wicri:noRegion>Basel</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Khoury, H Jean" sort="Khoury, H Jean" uniqKey="Khoury H" first="H. Jean" last="Khoury">H. Jean Khoury</name>
<affiliation wicri:level="1"><nlm:aff id="A10">Emory Clinic, Winship Cancer Institute, Atlanta, Georgia</nlm:aff>
<country xml:lang="fr">Géorgie (pays)</country>
<wicri:regionArea>Emory Clinic, Winship Cancer Institute, Atlanta</wicri:regionArea>
<wicri:noRegion>Atlanta</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mccarthy, Philip" sort="Mccarthy, Philip" uniqKey="Mccarthy P" first="Philip" last="Mccarthy">Philip Mccarthy</name>
<affiliation wicri:level="2"><nlm:aff id="A11">Roswell Park Cancer Institute, Buffalo, New York</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Roswell Park Cancer Institute, Buffalo</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Marks, David I" sort="Marks, David I" uniqKey="Marks D" first="David I" last="Marks">David I. Marks</name>
<affiliation wicri:level="1"><nlm:aff id="A12">United Bristol Healthcare Trust, Bristol, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>United Bristol Healthcare Trust, Bristol</wicri:regionArea>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Szer, Jeff" sort="Szer, Jeff" uniqKey="Szer J" first="Jeff" last="Szer">Jeff Szer</name>
<affiliation wicri:level="1"><nlm:aff id="A13">Royal Melbourne and Western Hospitals, Parkville, Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Royal Melbourne and Western Hospitals, Parkville, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Woolfrey, Ann" sort="Woolfrey, Ann" uniqKey="Woolfrey A" first="Ann" last="Woolfrey">Ann Woolfrey</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Fred Hutchinson Cancer Research Center, Seattle, Washington</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Cortes Franco, Jorge" sort="Cortes Franco, Jorge" uniqKey="Cortes Franco J" first="Jorge" last="Cortes-Franco">Jorge Cortes-Franco</name>
<affiliation wicri:level="2"><nlm:aff id="A14">University of Texas, M.D. Anderson Cancer Center, Houston, Texas</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>University of Texas, M.D. Anderson Cancer Center, Houston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Horowitz, Mary M" sort="Horowitz, Mary M" uniqKey="Horowitz M" first="Mary M" last="Horowitz">Mary M. Horowitz</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Center for International Blood and Marrow Transplant Research, Minneapolis, Minnesota</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Center for International Blood and Marrow Transplant Research, Minneapolis</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A15">Medical College of Wisconsin, Milwaukee, Wisconsin</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>Medical College of Wisconsin, Milwaukee</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Arora, Mukta" sort="Arora, Mukta" uniqKey="Arora M" first="Mukta" last="Arora">Mukta Arora</name>
<affiliation wicri:level="2"><nlm:aff id="A1">University of Minnesota, Minneapolis, Minnesota</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>University of Minnesota, Minneapolis</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A2">Center for International Blood and Marrow Transplant Research, Minneapolis, Minnesota</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Center for International Blood and Marrow Transplant Research, Minneapolis</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation</title>
<idno type="ISSN">1083-8791</idno>
<idno type="eISSN">1523-6536</idno>
<imprint><date when="2009">2009</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Purpose</title>
<p id="P1">Unrelated donor (URD) hematopoietic cell transplantation (HCT) can eradicate chronic myelogenous leukemia (CML). It has been postulated that greater donor:recipient-histoincompatibility can augment the graft vs. leukemia (GvL) effect. We previously reported similar, but not equivalent outcomes of URD vs. sibling donor HCT for CML using an older, less precise classification of HLA-matching.</p>
</sec>
<sec sec-type="methods" id="S2"><title>Methods</title>
<p id="P2">Our recently refined HLA-matching classification, suitable for interpretation when complete allele-level typing is unavailable was used to reanalyze outcomes of previous HCT for CML.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">We observed that new matching criteria identifies substantially more frequent mismatch than older, less precise “6 of 6 antigen” matched URD-HCT. Only 37% of those previously called “HLA-matched” were HLA-<underline>well-matched</underline>
in new classification and 44% were <underline>partially-matched</underline>
. The refined matching classification confirmed that partially matched or <underline>mismatched</underline>
URD:recipient pairs have significantly greater risks of graft failure compared to either sibling or well-matched URD-HCT. Acute and chronic GVHD are significantly more frequent with all levels of recategorized URD HLA-matching. Importantly, survival and leukemia-free survival remain significantly worse following URD-HCT at any matching level. No augmented GvL effect accompanied URD HLA-mismatch. Compared to sibling donor transplants, we observed marginally increased, but not significantly different risks of relapse in either well-matched, partially-matched or mismatched URD-HCT.</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">These data confirm the utility of our revised HLA-matching schema as applicable for analysis of retrospective data sets when fully informative, allele level-typing is unavailable. In this analysis, greater histoincompatibility can augment GVHD but does not improve protection against relapse thus the best donor is still the most closely matched.</p>
</sec>
</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>Espagne</li>
<li>France</li>
<li>Géorgie (pays)</li>
<li>Royaume-Uni</li>
<li>Suisse</li>
<li>États-Unis</li>
</country>
<region><li>Bourgogne-Franche-Comté</li>
<li>Californie</li>
<li>Franche-Comté</li>
<li>Massachusetts</li>
<li>Minnesota</li>
<li>Ohio</li>
<li>Texas</li>
<li>Washington (État)</li>
<li>Wisconsin</li>
<li>État de New York</li>
</region>
<settlement><li>Besançon</li>
</settlement>
</list>
<tree><country name="États-Unis"><region name="Minnesota"><name sortKey="Weisdorf, Daniel J" sort="Weisdorf, Daniel J" uniqKey="Weisdorf D" first="Daniel J." last="Weisdorf">Daniel J. Weisdorf</name>
</region>
<name sortKey="Antin, Joseph H" sort="Antin, Joseph H" uniqKey="Antin J" first="Joseph H" last="Antin">Joseph H. Antin</name>
<name sortKey="Arora, Mukta" sort="Arora, Mukta" uniqKey="Arora M" first="Mukta" last="Arora">Mukta Arora</name>
<name sortKey="Arora, Mukta" sort="Arora, Mukta" uniqKey="Arora M" first="Mukta" last="Arora">Mukta Arora</name>
<name sortKey="Bolwell, Brian" sort="Bolwell, Brian" uniqKey="Bolwell B" first="Brian" last="Bolwell">Brian Bolwell</name>
<name sortKey="Copelan, Edward" sort="Copelan, Edward" uniqKey="Copelan E" first="Edward" last="Copelan">Edward Copelan</name>
<name sortKey="Cortes Franco, Jorge" sort="Cortes Franco, Jorge" uniqKey="Cortes Franco J" first="Jorge" last="Cortes-Franco">Jorge Cortes-Franco</name>
<name sortKey="Gale, Robert" sort="Gale, Robert" uniqKey="Gale R" first="Robert" last="Gale">Robert Gale</name>
<name sortKey="Haagenson, Michael" sort="Haagenson, Michael" uniqKey="Haagenson M" first="Michael" last="Haagenson">Michael Haagenson</name>
<name sortKey="Horowitz, Mary M" sort="Horowitz, Mary M" uniqKey="Horowitz M" first="Mary M" last="Horowitz">Mary M. Horowitz</name>
<name sortKey="Horowitz, Mary M" sort="Horowitz, Mary M" uniqKey="Horowitz M" first="Mary M" last="Horowitz">Mary M. Horowitz</name>
<name sortKey="Lee, Stephanie J" sort="Lee, Stephanie J" uniqKey="Lee S" first="Stephanie J" last="Lee">Stephanie J. Lee</name>
<name sortKey="Lee, Stephanie J" sort="Lee, Stephanie J" uniqKey="Lee S" first="Stephanie J" last="Lee">Stephanie J. Lee</name>
<name sortKey="Mccarthy, Philip" sort="Mccarthy, Philip" uniqKey="Mccarthy P" first="Philip" last="Mccarthy">Philip Mccarthy</name>
<name sortKey="Nelson, Gene" sort="Nelson, Gene" uniqKey="Nelson G" first="Gene" last="Nelson">Gene Nelson</name>
<name sortKey="Spellman, Stephen" sort="Spellman, Stephen" uniqKey="Spellman S" first="Stephen" last="Spellman">Stephen Spellman</name>
<name sortKey="Weisdorf, Daniel J" sort="Weisdorf, Daniel J" uniqKey="Weisdorf D" first="Daniel J." last="Weisdorf">Daniel J. Weisdorf</name>
<name sortKey="Woolfrey, Ann" sort="Woolfrey, Ann" uniqKey="Woolfrey A" first="Ann" last="Woolfrey">Ann Woolfrey</name>
</country>
<country name="France"><region name="Bourgogne-Franche-Comté"><name sortKey="Cahn, Jean Yves" sort="Cahn, Jean Yves" uniqKey="Cahn J" first="Jean-Yves" last="Cahn">Jean-Yves Cahn</name>
</region>
</country>
<country name="Espagne"><noRegion><name sortKey="Cervantes, Francisco" sort="Cervantes, Francisco" uniqKey="Cervantes F" first="Francisco" last="Cervantes">Francisco Cervantes</name>
</noRegion>
</country>
<country name="Suisse"><noRegion><name sortKey="Gratwohl, Alois" sort="Gratwohl, Alois" uniqKey="Gratwohl A" first="Alois" last="Gratwohl">Alois Gratwohl</name>
</noRegion>
</country>
<country name="Géorgie (pays)"><noRegion><name sortKey="Khoury, H Jean" sort="Khoury, H Jean" uniqKey="Khoury H" first="H. Jean" last="Khoury">H. Jean Khoury</name>
</noRegion>
</country>
<country name="Royaume-Uni"><noRegion><name sortKey="Marks, David I" sort="Marks, David I" uniqKey="Marks D" first="David I" last="Marks">David I. Marks</name>
</noRegion>
</country>
<country name="Australie"><noRegion><name sortKey="Szer, Jeff" sort="Szer, Jeff" uniqKey="Szer J" first="Jeff" last="Szer">Jeff Szer</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 007B62 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 007B62 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Asie |area= AustralieFrV1 |flux= Main |étape= Exploration |type= RBID |clé= PMC:2929002 |texte= Sibling versus Unrelated Donor Allogeneic Hematopoietic Cell Transplantation for CML: Refined HLA-matching shows more GVHD but not less relapse }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:19822308" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a AustralieFrV1
This area was generated with Dilib version V0.6.33. |